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Conquering the Endgame: A Guide to Diablo 4 Season 6 Bosses

By Ansley
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Diablo 4 Season 6 introduces a host of formidable endgame bosses that challenge even the most seasoned adventurers. This guide will cover the locations, summoning materials, and loot drops for these fearsome foes.

 

The endgame Boss is a particular Boss that can be summoned by collecting summoning materials at the end of the game and is an essential part of the gameplay content.

 

1. Dropped Mythic Unique Items

 

All endgame bosses can drop the Diablo 4 Mythic Unique items.

 

Duriel and Andariel are not guaranteed to drop Mythic Unique but are twice as likely to drop Mythic Unique as any other end Boss.

 

Class

Dropped Mythic Unique

Barbarian

The Grandfather

Shattered Vow

Doombringer

Druid

Ahavarion, Spear of Lycander

Shattered Vow

Doombringer

Necromancer

The Grandfather

Doombringer

Rogue

Doombringer

Sorcerer

Ahavarion, Spear of Lycander

Doombringer

Spiritborn

Nesekem, the Herald

Shattered Vow

All Classes

Melted Heart of Selig

Tyrael's Might

Andariel's Visage

Harlequin Crest

Ring of Starless Skies

Shroud of False Death

Heir of Perdition

 

2. The Infernal Hordes

 

The Infernal Hordes is a new activity introduced in Season 5.

 

•  Summoning Materials: Infernal Compass

 

•  Loot

Class

Dropped Unique Items

Barbarian

The Third Blade

Druid

The Basilisk

Necromancer

The Mortacrux

Rogue

The Umbracrux

Sorcerer

Vox Omnium

All Classes

Locran's Talisman

Rakanoth's Wake

Endurant Faith

Crown of Lucion

Shard of Verathiel

 

3. Loot from Endgame Bosses

The items listed below have a higher chance of falling from this Boss. Players will still drop unique items that are not on the list and will not always drop unique items each time they kill a Boss.

 

(1). Andariel

•  Location: Hanged Man's Hall.

 

•  Summoning Materials: Pincushioned Doll x 2 Sandscorched Shackles x 2.

 

•  Loot: Drops exclusive cosmetics, specific uniques, and a chance to drop Mythics unique.

 

(2). Duriel

•  Location: Kehjistan level 100 dungeon Gaping Crevasse.

 

•  Summoning Materials: Mucus Slick Eggs x 2 Shards of Agony x 2.

 

•  Loot: Known for dropping high-tier gear and unique items, and a chance to drop Mythics unique.

 

(3). Loot from Andariel and Duriel

 

Class

Dropped Unique Items

Barbarian

Tuskhelm of Joritz the Mighty

Azurewrath

Druid

Dolmen Stone

Tempest Roar

Azurewrath

Necromancer

Black River

Blood Moon Breeches

Azurewrath

Rogue

Scoundrel's Leathers

Cowl of the Nameless

Azurewrath

Sorcerer

Blue Rose

Flamescar

Azurewrath

Spiritborn

Sepazontec

Rod of Kepeleke

All Classes

Godslayer Crown

Flickerstep

Tibault's Will

X'Fal's Corroded Signet

Soulbrand

Banished Lord's Talisman

 

(4). Echo of Varshan

•  Location: Tree of Whispers - Malignant Burrow dungeon.

 

•  Summoning Materials: Malignant Heart x 4.

 

•  Loot: Offers exclusive cosmetics, unique items, and a chance for Mythic drops.

 

Class

Dropped Unique Items

Barbarian

100,000 Steps

Gohr's Devastating Grips

Ring of Red Furor

Fields of Crimson

Druid

Mad Wolf's Glee

Vasily's Prayer

Airidah's Inexorable Will

Greatstaff of the Crone

Necromancer

Deathspeaker's Pendant

Deathless Visage

Ring of the Sacrilegious Soul

Bloodless Scream

Rogue

Skyhunter

Condemnation

Eyes in the Dark

Writhing Band of Trickery

Sorcerer

Esu's Heirloom

Raiment of the Infinite

Tal Rasha's Iridescent Loop

Staff of Endless Rage

Spiritborn

Craze of the Dead God

Ring of Writhing Moon

Ring of the Midday Hunt

All Classes

Frostburn

Mother's Embrace

 

(5). Grigoire

•  Location: Dry Steppes - the Hall of the Penitent dungeon.

 

•  Summoning Materials: Living Steel x 12.

 

•  Loot: Drops include unique items, Diablo 4 gold, and a chance for Mythic Unique drops.

 

Class

Dropped Unique Items

Barbarian

Battle Trance

The Butcher's Cleaver

Rage of Harrogath

Twin Strikes

Unbroken Chain

Druid

Waxing Gibbous

The Butcher's Cleaver

Insatiable Fury

Hunter's Zenith

Earthbreaker

Necromancer

Ebonpiercer

Greaves of the Empty Tomb

Howl from Below

Path of Trag'Oul

The Butcher's Cleaver

Rogue

Word of Hakan

Grasp of Shadow

Saboteur's Signet

Shroud of Khanduras

Sorcerer

Flameweaver

Iceheart Brais

Staff of Lam Esen

Axial Conduit

Spiritborn

Peacemonger's Signet

Ring of the Midnight Sun

All Classes

Penitent Greaves

 

(5). Lord Zir

•  Location: The Darkened Way dungeon in Kehjistan.

 

•  Summoning Materials: Exquisite Blood x 12

 

•  Loot

Class

Dropped Unique Items

Barbarian

Arreat's Bearing

Overkill

Ramaladni's Magnum Opus

Druid

Wildheart Hunger

Fleshrender

Mjölnic Ryng

Necromancer

Cruor's Embrace

Lidless Wall

Rogue

Asheara's Khanjar

Scoundrel's Kiss

Sorcerer

Esadora's Overflowing Cameo

Fractured Winterglass

Spiritborn

Jacinth Shell

Wushe Nak Pa

Band of First Breath

All Classes

Yen's Blessing

Razorplate

Temerity

 

(6). The Beast in the Ice

•  Location: In the Glacial Fissure dungeon

 

•  Summoning Materials: Distilled Fear x 12

 

•  Loot

Class

Dropped Unique Items

Barbarian

Ancients' Oath

Hellhammer

Ring of the Ravenous

Druid

Unsung Ascetic's Wraps

Storm's Companion

Necromancer

Mutilator Plate

Ring of Mendeln

Rogue

Beastfall Boots

Windforce

Eaglehorn

Sorcerer

Gloves of the Illuminator

Starfall Coronet

The Oculus

Spiritborn

Scorn of the Earth

Harmony of Ebewaka

Wound Drinker

All Classes

Fists of Fate

Paingorger's Gauntlets

Tassets of the Dawning Sky

 

Conclusion

Facing these endgame bosses tests your skills and rewards you with some of the best loot in Diablo 4. Prepare well, gather your resources, and dive into the fray to conquer these mighty adversaries.

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